Scoping review of the Zika Virus literature

Added November 7, 2016

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More than half the primary literature on ZIKV has been published since 2011, this has coincided with outbreaks in Australasia (2007) and the Americas (2016). Several knowledge gaps remain with respect to ZIKV epidemiology, the importance of potential non-human primates and other hosts in the transmission cycle, the burden of disease in humans, and complications related to human infection with ZIKV.

For over sixty years, ZIKV (a Flavivirus transmitted by Aedes spp. Mosquitos) has not been well researched. However, due to the recent spread across continents and a reported clinical pattern of Guillain-Barre’s syndrome, studies on ZIKV have increased. The aim of this scoping review was to systematically capture all published literature covering (1) ZIKV infection in humans, (2) studies on ZIKV, (3) prevention strategies against ZIKV infections, and (4) societal knowledge, perception and attitudes towards ZIKV. There were 233 relevant studies identified from 1952 to March 1, 2016. Three topic areas were covered: epidemiology 56.6%(132/233), pathogenesis 38.2%(89/233) and molecular characterisation and in vitro evaluation 18.5%(43/233. Little was reported for ZIKV vectors (12/233), surveillance (13/233), diagnostic tests (12/233) and transmission (10/233).Only English and French articles were included.