Herd immunity to Ebola viruses is not a realistic target for current vaccination strategies

Added June 14, 2020

Citation: Masterson SG, Lobel L, Carroll MW, Wass MN, Michaelis M. Herd immunity to Ebolaviruses is not a realistic target for current vaccination strategies. Frontiers in immunology. 2018 May 9;9:1025.

Summary: It was found that more than 80% of a population need to be vaccinated to establish herd immunity. These rates are currently unrealistic, due to vaccination resistance, financial and logistical challenges, and a lack of vaccines that provide long-term protection against all human-pathogenic Ebola viruses.

This systematic review analyzed the requirements for a prophylactic vaccination program based on the basic reproductive number (the number of secondary cases that results from an individual infection). It is anticipated that outbreak management for the foreseeable future will depend on surveillance and case isolation. Clinical vaccine candidates are available only for Ebola viruses. The use of such vaccines must be focused on health-care workers, possibly in combination with ring vaccination approaches.


Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence on Ebola but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about Ebola on the basis of this summary alone.