Ebola virus infection overview and update on prevention and treatment

Added June 14, 2020

Citation: Martínez MJ, Salim AM, Hurtado JC, Kilgore PE. Ebola virus infection: overview and update on prevention and treatment. Infectious diseases and therapy. 2015 Dec 1;4(4):365-90.

Summary: A comprehensive literature search was done of publications from 1993 to 2015 to provide an update on the 2014/15 Ebola virus disease (EVD) outbreak and to review progress in prevention and treatment strategies. 156 studies were identified and used.

The review covers virology, epidemiology, human transmission and the clinical syndrome. Laboratory tests needed to diagnose EVD are described including newly developed rapid antigen detection tests and nucleic acid detection (NAT) tests.  The Therapy section includes supportive care, targeted antiviral compounds/drugs, immunotherapy, and ebola vaccine candidates.  An assessment of future directions is also made.


Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence on Ebola but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about Ebola on the basis of this summary alone.