Drugs for treating Schistosomiasis mansoni infection

Added April 10, 2013

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The available evidence supports single dose praziquantel at 40 mg/kg as standard treatment for S. mansoni infection as recommended by the WHO. Oxamniquine, a largely discarded alternative, appears efficacious and production and distribution should continue to ease selective pressure on praziquantel. However, its use should be limited to areas without S. haematobium co-endemicity.

Schistosoma mansoni is a parasitic infection common in the tropics and sub-tropics. Chronic and advanced disease includes abdominal pain, diarrhoea, blood in the stool, liver cirrhosis, portal hypertension, and premature death. This review evaluates the effects of antischistosomal drugs, used alone or in combination, for treating S. mansoni infection.