Antibiotics for community acquired pneumonia in children
The evidence from RCTs on the effectiveness of various antibiotics for community-acquired pneumonia (CAP) in children varies. For the treatment of patients with CAP in ambulatory setting, amoxycillin can be used as an alternative to co-trimoxazole. The limited data available on other antibiotics suggest that co-amoxyclavulanic acid and cefpodoxime may be used as alternatives in second-line therapy. Children with severe pneumonia but without hypoxaemia may be treated with oral amoxycillin in ambulatory settings. Additionally, children hospitalised with severe or very severe pneumonia may be given penicillin/ampicillin plus gentamycin as the preferred choice to chloramphenicol. Other alternative antibiotics for severe and very severe pneumonia are co-amoxyclavulanic acid and cefuroxime that may be used as second-line therapies.
Pneumonia in children is associated with high mortality rates, particularly in low income settings or countries. Early administration of antibiotics is associated with improved health outcomes. The aim of this review was to identify effective antibiotic drug therapies for community acquired pneumonia (CAP) of varying severity in children through a comparison of various antibiotics.
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