Vitamin E supplementation in pregnancy
Citation: Rumbold A, Ota E, Hori H, et al. Vitamin E supplementation in pregnancy. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD004069. DOI: 10.1002/14651858.CD004069.pub3.
The data do not support routine vitamin E supplementation in combination with other supplements for the prevention of stillbirth, neonatal death, preterm birth, pre‐eclampsia, preterm or term PROM or poor fetal growth. There was no convincing evidence that vitamin E supplementation in combination with other supplements results in other important benefits or harms.
Vitamin E supplementation may help reduce the risk of pregnancy complications involving oxidative stress, such as pre‐eclampsia. There is a need to evaluate the efficacy and safety of vitamin E supplementation in pregnancy. This review aims to assess the effects of such supplementation, alone or in combination with other separate supplements, on pregnancy outcomes, adverse events, side effects, and use of health services.