Vasopressors for hypotensive shock

Added March 17, 2020

Citation: Gamper G, Havel C, Arrich J, et al. Vasopressors for hypotensive shock. Cochrane Database of Systematic Reviews 2016; (2): CD003709

What is this? Some patients with COVID-19 will become critically ill and may develop hypotensive shock, but there is uncertainty about the most beneficial way to treat this. Vasopressors have shown evidence of benefit in hypotensive shock, probably because of their ability to raise blood pressure. Their effects for patients with hypotensive shock caused by other factors might indicate their effects in patients with COVID-19.

In this Cochrane systematic review, the authors searched for randomized trials comparing different vasopressor regimens on mortality in critically ill patients with hypotensive shock. They did not restrict by date, type or language of publication and did their most recent search in June 2015. They identified 28 studies (3497 participants), covering six different vasopressors.

What works: Vasopressor therapy is an important part of haemodynamic support for patients with shock.

What doesn’t work: Nothing noted.

What’s uncertain: It is uncertain whether any of the vasopressors at assessed doses are superior to others for mortality.

 

Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence on the coronavirus (COVID-19) but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about the coronavirus (COVID-19) on the basis of this summary alone.

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