Vaccines for measles, mumps and rubella in children
Citation: Demicheli V., Rivetti A., Debalini M.G., et al. Vaccines for measles, mumps and rubella in children. Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No.:CD004407. DOI:10.1002/14651858.CD004407.pub3.
No significant association was found between MMR immunization and the following conditions: autism, asthma, leukemia, hay fever, type 1 diabetes, gait disturbance, Crohn’s disease, demyelinating diseases, or bacterial or viral infections.
Mumps, measles, and rubella (MMR) are serious diseases that can lead to potentially fatal illness, disability, and death. However, public debate over the safety of the trivalent MMR vaccine and the resultant drop in vaccination coverage in several countries persists, despite its almost universal use and accepted effectiveness. This review included 64 eligible studies that assessed the effectiveness and adverse effects associated with the MMR vaccine in children up to 15 years of age. Vaccine effectiveness of protection against MMR diseases ranged from 64% to 98% effective in participants. In certain studies, the vaccine containing specific strains of MMR were found to be associated with aseptic meningitis, febrile convulsion (in children younger than 5yrs old), and idiopathic thrombocytopaenic purpura. The methodological quality of many of the included studies made it difficult to generalize their results.
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