Treatments for COVID-19: evidence from SARS and MERS is insufficient to support clear recommendations
Citation: Zhong H, Wang Y, Zhang ZL, et al. Efficacy and safety of current therapeutic options for COVID-19 – lessons to be learnt from SARS and MERS epidemic: A systematic review and meta-analysis. Pharmacological Research 2020; 157: 104872.
What is this? The virus that causes COVID-19, SARS-CoV-2 is a coronavirus like those that caused severe acute respiratory syndrome (SARS) and Middle Eastern respiratory syndrome (MERS). Existing research for those conditions might provide useful information on treatment options for patients with COVID-19
In this rapid review, the authors searched for randomised trials or cohort studies evaluating the efficacy and safety of anti-coronavirus agents. They did not limit by language of publication and did their search on 14 April 2020. They identified 5 randomised trials, 2 prospective cohort studies and 11 retrospective cohort studies; and judged the evidence to be very low quality. Seven studies included patients with COVID-19.
What was found: Based on the studies included in their review, the authors were unable to draw clear conclusions that would support recommendations for potential therapies for COVID-19.
Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence on the coronavirus (COVID-19) but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about the coronavirus (COVID-19) on the basis of this summary alone.
If you have found this summary helpful, please consider making a donation. If everyone who looked at our COVID-19 resources gave us just £2 per month, it would fund Evidence Aid’s life-saving work.