Travel-associated Zika Virus Disease acquired in the Americas through February 2016: A geosentinel analysis

Added March 14, 2017

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Surveillance data helps to identify the clinical manifestations and adverse outcomes of Zika virus disease among travellers and demonstrates a need for global standardization of diagnostic testing; in particular travel advisories and prevention measures for pregnant women and their partners.

The aim of the review was to understand the extent of Zika virus disease in global travellers from the Americas and the characteristics of the infections. Zika virus cases were identified from the GeoSentinel Surveillance Network. Ill returned travellers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016 were included. Cases were identified from 63 travel and tropical medicine clinics in 30 countries. 93 cases were identified; they were predominantly female (62%) who had travelled for tourism (49%). South America (59%) was the main region of exposure followed by the Caribbean (25%) and Central America (16%). The main region for diagnosis was Western Europe (71%) followed by N America (17%). Common symptoms included exanthema (88%), fever (76%), and arthralgia (72%). Two patients developed Guillain–Barre syndrome, and 3 of 4 pregnancies had adverse outcomes (microcephaly, major fetal neurologic abnormalities, and intrauterine fetal death).