Sinonasal pathophysiology of SARS‐CoV‐2 and COVID‐19 (search done: 30 March 2020)

Added May 15, 2020

Citation: Gengler I, Wang JC, Speth MM, et al. Sinonasal pathophysiology of SARS‐CoV‐2 and COVID‐19: A systematic review of the current evidence. Laryngoscope Investigative Otolaryngology. 2020 Apr 10.

What is this? One possible route of transmission of the SARS-Cov-2 virus is through the sinonasal tract of patients with COVID-19.

In this rapid review, the authors searched for studies that evaluated nasal and sinonasal pathophysiology in COVID-19 patients. They restricted their search to articles published in English or Chinese and did their most recent search on 30 March 2020. They included 19 studies. They also identified an additional two studies, which are awaiting assessment.

What was found: Based on the studies available at the time of this review, the sinonasal tract cavity may be an important site for infection and sinonasal viral shedding may be an important transmission mechanism, including for healthcare‐associated infection.

Based on the studies available at the time of this review, anosmia without nasal obstruction may be a highly specific indicator of COVID‐19.


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