Middle East respiratory syndrome coronavirus: review of multiple aspects of MERS
Citation: Dawson P, Malik MR, Parvez F, et al. What have we learned about Middle East respiratory syndrome coronavirus emergence in humans? A systematic literature review. Vector-Borne and Zoonotic Diseases. 2019 Mar 1;19(3):174-92.
What is this? COVID-19 is caused by the respiratory coronavirus, SARS-CoV-2. This is similar to Middle East respiratory syndrome (MERS) and research on MERS-CoV might provide useful information for policy makers responding to the COVID-19 pandemic.
In this systematic review, the authors searched for studies on about MERS-CoV. They restricted their search to articles published in English between 2012 and July 2017 and did the search in 2018. They included 208 studies, covering virology, clinical characteristics, outcomes, therapeutic and preventive options, epidemiology and transmission, animal interface and the search for natural hosts of MERS-CoV.
What was found: At the time of this review, the included studies showed that various potential therapeutics had been identified, but not evaluated in human clinical trials.
At the time of this review, the included studies showed that one potential vaccine for MERS had progressed to phase I trials.
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