Medical approaches for Middle East respiratory syndrome (MERS)

Added April 2, 2020

Citation: Morra ME, Van Thanh L, Kamel MG, et al. Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis. Reviews in Medical Virology 2018; 28: e1977

What is this? Like COVID-19, Middle East respiratory syndrome (MERS) is an acute respiratory disease caused by a coronavirus. Some of the drugs given to patients with MERS are being considered for the treatment of patients with COVID-19.

In this systematic review, the authors searched for research evaluating the treatment of patients with MERS. They restricted their search to articles published after 1 January 2012 but did not restrict by language of publication. They did their search in June 2015. They identified 10 case reports, 4 observational studies and 2 case series.

What works: The combination of ribavirin and interferon might be effective for the treatment of MERS, if given promptly and with monitoring of adverse events.

What doesn’t work: Corticosteroids did not show benefits on survival of patients with MERS.

Interferon did not show benefits on mortality rate or duration of survival for patients with MERS.

What’s uncertain: Nothing noted.

 

Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence on the coronavirus (COVID-19) but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about the coronavirus (COVID-19) on the basis of this summary alone.

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