Liver injuries and COVID-19 (search done on 17 March 2020)

Added August 4, 2020

Citation: Kukla M, Skonieczna-Żydecka K, Kotfis K, Maciejewska D, Łoniewski I, Lara L, Pazgan-Simon M, Stachowska E, Kaczmarczyk M, Koulaouzidis A, Marlicz W. COVID-19, MERS and SARS with Concomitant Liver Injury – Systematic Review of the Existing Literature. Journal of Clinical Medicine. 2020 May;9(5):1420.

What is this? Some patients with COVID-19 might develop concomitant liver injury.

In this rapid systematic review, the authors searched for studies that evaluated the incidence of hepatic abnormalities in patients infected with SARS CoV-1, SARS CoV-2 or MERS with reported liver-related parameters. They restricted their search to articles published in English and did the search on 17 March 2020. They included 43 studies (total: 4591 participants), which included patients with SARS CoV-1 (23 studies), SARS CoV-2 (11) and MERS (9).

What was found: At the time of this review, the included studies showed that liver anomalies were predominantly mild to moderately elevated transaminases, hypoalbuminemia and prolongation of prothrombin time.

At the time of this review, the included studies showed that the histopathology varied between non-specific inflammation, mild steatosis, congestion and massive necrosis.

 

Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence on the coronavirus (COVID-19) but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about the coronavirus (COVID-19) on the basis of this summary alone.

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