Interventions with vitamins B6, B12 and C in pregnancy
Citation: Dror D.K., & Allen L.H. Interventions with Vitamins B6, B12 and C in Pregnancy. Paediatric and Perinatal Epidemiology, 2012;26(1):55–74. doi:10.1111/j.1365-3016.2012.01277.x
Existing evidence does not justify vitamin C supplementation during pregnancy. Additional studies are needed to confirm positive effects of vitamin B6 supplementation on infant birthweight and other outcomes. While vitamin B12 supplementation may reduce the incidence of neural tube defects in the offspring based on theoretical considerations, research is needed to support this hypothesis.
Vitamins B6, B12 and C are important to maternal and fetal outcomes during gestation. This review aimed to assess the effectiveness of B6, B12 and C interventions during pregnancy on maternal, neonatal and child health and nutrition outcomes. Meta-analyses was conducted where at least three trials were found for outcomes. Tailored GRADE criteria was used to assess the quality of included trials for bias. Results found vitamin B6 supplementation had a significant positive effect on birthweight. Vitamin C, or C combined with E, interventions were shown to increase the risk of pregnancy related hypertension and did not reduce incidences of pre-eclampsia, premature rupture of membranes, or other adverse pregnancy outcomes. No significant results were found for the effect of B6 or C interventions on other neonatal outcomes. No intervention trials were found for B12 supplementation. A gap in evidence and research on the effects of B6, B12 and C supplementation during pregnancy was observed.
Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence the prevention and treatment of malnutrition but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about prevention or treatment of malnutirition on the basis of this summary alone.
If you have found this summary helpful, please consider making a donation. If everyone who looked at our COVID-19 resources gave us just £2 per month, it would fund Evidence Aid’s life-saving work.