Intermittent versus daily therapy for treating tuberculosis in children
Evidence from four randomised trials was insufficient to determine that the use of daily drug treatment was more effective than intermittent (twice- or thrice-weekly) treatment for children with tuberculosis.
Childhood tuberculosis is a neglected global public health problem. Rifampicin-containing drugs given daily for six months cure over 90% of infected children, but poor adherence and supervision reduces treatment success. The aim of the review was to establish if daily anti-tuberculosis treatments were better than intermittent treatments.