Intermittent preventive treatment for malaria in infants

Added August 27, 2020

Citation: Esu  EB, Oringanje  C, Meremikwu  MM. Intermittent preventive treatment for malaria in infants. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD011525.

Giving sulfadoxine‐pyrimethamine (SP) as preventive antimalarial treatment to infants probably reduces the risk of clinical malaria, anaemia, and hospital admissions in the African countries. However, this effect was attenuated in more recent studies. Giving artemisininbased combination therapy (ACT) as preventive antimalarial treatment to infants may reduce the risk of clinical malaria. It may also reduce the proportion of infants with malaria parasites in their blood.

Intermittent preventive treatment could help prevent malaria in infants (IPTi) living in areas of moderate to high malaria transmission in sub‐Saharan Africa. The World Health Organization (WHO) policy recommended IPTi in 2010, but its adoption in countries has been limited. This Cochrane review aimed to find out if administering repeated doses of antimalarial treatment to infants living in sub‐Saharan Africa can prevent malaria. Results were analysed from 12 relevant studies conducted between 1999 and 2013 that addressed this question in infants (defined as young children aged between 1 to 12 months).


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