Effects of prenatal multimicronutrient supplementation on pregnancy outcomes

Added March 9, 2018

Citation: Shah P.S., Ohlsson A. Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis. Canadian Medical Association Journal, 2009;180(12):99-108

Prenatal supplementation with multimicronutrients was associated with a significantly reduced risk of low-birth-weight infants and with improved birth weight when compared with iron–folic acid supplementation. We found no effect of multimicronutrient supplementation on the risk of preterm birth or small-for-gestational-age infants. 

Inadequate intake of micronutrients during pregnancy may result in nutritional deficiencies, that in turn may influence fetal growth. This review aimed to assess the effects of micronutrient intake during pregnancy on fetal and infant growth. Thirteen studies were included, utilizing a randomized or quasi-randomized control design, and were judged to be of high quality using the Cochrane risk of bias tool. Meta-analysis found a significant reduction in the risk of low birth weight for the children of women who received micronutrients during pregnancy. No significant result was found between micronutrient intake during pregnancy and pre-term birth or small-for-gestational-age infants.


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