Effect of multiple micronutrient supplementation on pregnancy and infant outcomes

Added March 13, 2018

Citation: Ramakrishnan U., Grant F.K., Goldenberg T., et al. Effect of multiple micronutrient supplementation on pregnancy and infant outcomes: A systematic review. Paediatric and Perinatal Epidemiology 2012;26(1):153-67

None of the studies evaluated maternal morbidity. Compared with iron plus folic acid supplementation alone, prenatal maternal supplementation with MM resulted in a reduction in the incidence of low birthweight and SGA but increased risk of neonatal death in the subgroup of studies that began the intervention after the first trimester.

Multiple micronutrient (MM) supplementation during pregnancy can have a positive effect on pregnancy and infant outcomes. This review aimed to assess the effects of such supplementation on low birthweight, birthweight, small-for-gestational age (SGA), gestational age, preterm birth, stillbirth and neonatal death, maternal morbidity and mortality. This review included 16 studies for meta-analysis on timing of intervention and amounts of iron included in supplementation. Results showed MM supplementation significantly reduced incidences of low birth weight and increased mean birth weight.  No significant effect of MM supplementation was observed on risk of preterm birth, stillbirth, and maternal or neonatal mortality. An increased risk of neonatal death was observed in subgroup comparison for MM versus iron-folate, when intervention occurred after the trimester. Prenatal MM supplementation reduced incidences of low birth weight and SGA and an increase in neonatal death where intervention occurred after the first trimester.


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