Diagnostics, vaccine and therapeutics for COVID-19 (rapid review)

Added April 2, 2020

Citation: Pang J, Wang MX, Ang IYH, et al. Potential rapid diagnostics, vaccine and therapeutics for 2019 novel coronavirus (2019-nCoV): a systematic review. Journal of Clinical Medicine 2020; 9(3): E623

What is this? As research is done to develop or identify diagnostic tests, vaccines and treatments for COVID-19, multiple rapid reviews are being done of these topics.

In this rapid systematic review, the authors searched for randomized trials and validation trials for diagnostic tests evaluating rapid diagnostic tests, the impact of drug therapy and vaccine efficacy for coronaviruses generally. In addition, for COVID-19 specifically, they searched for in vitro, animal or human studies published in English between 1 December 2019 and 6 February 2020. They restricted their searches to articles published in English. They did their search on 6 February 2020. They identified 16 studies of diagnostics, 7 of therapeutics and 4 of vaccines.

What works:  At the time of the review (February 2020), one test (Beijing Genome Institute (BGI)) had been approved for use in the clinical setting for rapid diagnosis of COVID-19 and was being widely used in China.

What doesn’t work: Nothing noted.

What’s uncertain: At the time of the review (February 2020), there were several ongoing studies of interventions for COVID-19 but the effects of these were uncertain.


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