Daily sedation interruption versus no daily sedation interruption for adults requiring mechanical ventilation: uncertain effects

Added April 5, 2020

Citation: Burry L, Rose L, McCullagh IJ, et al. Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation. Cochrane Database of Systematic Reviews 2014; (7): CD009176

What is this? Some patients with COVID-19 will develop respiratory failure and need help with their breathing. This might be provided by mechanical ventilation (MV) in an intensive care unit (ICU). This requires the patient to be sedated, which can cause complications. Daily sedation interruption might be used to try to reduce these.

In this Cochrane systematic review, the authors searched for randomized trials comparing DSI with other sedation strategies for critically ill adults receiving MV. They did not restrict by language of publication and did their searches in February 2014. They identified 9 randomized trials (1282 participants). They also identified one study awaiting classification and one ongoing trial.

What works: Nothing noted.

What doesn’t work: Nothing noted.

What’s uncertain: Although the review found no strong evidence that daily sedation interruption alters clinical outcomes for critically ill adults receiving mechanical ventilation compared to sedation strategies that do not include DSI, the effects are uncertain because of the variability in the included studies.


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