Benefits of iron supplementation for low birth weight infants

Added March 9, 2018

Citation: Long H., Yi J., Hu P., et al. Benefits of iron supplementation for low birth weight infants: A systematic review. BMC Pediatrics. 2012;12(99);1-11

Iron supplementation increases the levels of hematologic indicators of iron status and reduces the prevalence of Iron-deficiency Anemia /Iron Deficiency (IDA/ID) in low birth weight/premature infants. There is insufficient evidence to make a definitive statement regarding the effects of iron supplementation on growth, neurodevelopment, or the occurrence of adverse effects in low birth weight/premature infants.

Infants with low birth weight may be susceptible to Iron Deficient Anemia. Studies have been conducted to assess the effects of iron supplementation (IS) on premature and infants with low birth weight. This paper reviewed such studies in order to examine the effects of IS on hematologic iron status, growth, neurodevelopment and the adverse effects IS may have.  Fifteen studies were reviewed, study quality was assessed using the Delphi list for quality assessment of randomized clinical trials. The review found a significant increase in hematologic iron status using IS, compared to a placebo. A decrease in prevalence of IDA was found with IS. No significant effect of IS on growth nor neurodevelopment was found. No consistently observed adverse effects of IS were found.

 

Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence the prevention and treatment of malnutrition but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about prevention or treatment of malnutirition on the basis of this summary alone.

Share